Primary Antibodies

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

APC2 / ANAPC2 antibody

Figure 1. Conjugation pathways for ubiquitin and
ubiquitin-like modifiers (UBLs). Most modifiers mature by proteolytic processing from inactive precursors (a; amino acid).
Arrowheads point to the cleavage sites. Ubiquitin is expressed either as polyubiquitin or as a fusion with ribosomal proteins. Conjugation requires activating (E1) and conjugating (E2) enzymes that form thiolesters (S) with the modifiers. Modification of cullins by RUB involves SCF(SKP1/cullin-1/F-box protein)/CBC(cullin-2/elongin
B/elongin C)-like E3 enzymes that are also involved in ubiquitination.
In contrast to ubiquitin, the UBLs do not seem to form multi-UBL chains. UCRP(ISG15) resembles two ubiquitin moieties linked headto-
tail. Whether HUB1 functions as a modifier is currently unclear.
APG12 and URM1 are distinct from the other modifiers because they are unrelated in sequence to ubiquitin. Data contributed by S. Jentsch, see ref. 3. Rabbit Serum Hu E, IP, WB
0.1 ml / $515.00
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